Frances was born on 27 September 1765 in Southwark and was Christened on 3 October at St Leonard's Church, Streatham. Named after Mrs. Thrale's sister, Frances only lived ten days after birth dying of infant diarrhoea.
She died on 6 October 1765 in Southwark and was buried on 8 October 1765 (no monument) at St. Leonard's Church, Streatham. During and after the birth Mrs. Thrale was under great stress from rushing around as Mr. Thrale successfully pursued a position in Parliament after Alexander Hume had died leaving a position open. Mr. Thrale announced his running four days before Frances was born.